新葡萄京娱乐场

生科院专题学术讲座 | Ting He:A new era of cancer therapy: CAR-T

来源:生命科学学院 发布时间:2019-09-29 作者:生命科学学院

时间:2019年10月11日 (周五) 上午10:00-11:00

Time:October 11, 2019, 10:00-11:00 AM

地点:新葡萄京娱乐场云栖校区5号楼1楼报告厅

Venue: Lecture Hall, 1st Floor, Build 5, Yunqi Campus

主持人:生命科学学院卢培龙博士

Host:Dr. Peilong Lu, School of Life Sciences, Westlake University


主讲嘉宾/Speaker:



Dr. Ting He

CEO of ImmunoChina Pharmaceuticals

讲座摘要/Abstract:

CD19-targeted chimeric antigen receptor-T (CAR-T) cells with CD28 or 4-1BB co-stimulatory domains (28z CAR-T and BBz CAR-T) have been approved by FDA to treat relapsed or refractory (r/r) B cell hematological malignancies. However, comparison of their clinical outcomes has never been reported. We established self-innovative platform technology of CAR-T manufacture, and investigated the clinical performances of both CAR-T types in B-ALL and B-NHL therapy based on exploratory clinical trials. Results showed that BBz CAR-T achieved higher complete response rate than 28z CAR-T in B-ALL therapy, and similar overall response rate was observed in B-NHL therapy. Most importantly, BBz CAR-T was well tolerated, however, 28z CAR-T induced severe cytokine release syndrome and neurotoxicity in B-ALL and B-NHL therapy. Our study suggests that 4-1BB is more beneficial for the clinical performance of CAR-T cells than CD28 in CD19-targeted therapy, at least under our manufacturing process.


联系人/Contact:

生命科学学院
于文越 yuwenyue@westlake.edu.cn




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